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珠玖 洋:免疫療法の展望、最新医学 58、57-67、2003
珠玖 洋:がんワクチンの現状. 最新医学 57、101-107、2002
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生田安司、王立杰、珠玖 洋:免疫療法 現状と展望 HER 2を標的とした免疫治療の新しい展開 疎水化多糖類と樹状細胞、日本臨床免疫学会会誌、22、445-447、1999

・ Nishikawa H, Kato T, Hirayama M, Orito Y, Sato E, Harada N, Gnjatic S, Old LJ, Shiku H.: Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling. Cancer Res. 2008 Jul 15;68(14):5948-54.
・ Harada N, Hoshiai K, Takahashi Y, Sakaguchi Y, Kuno T, Hishida T, Shiku H.: Preclinical safety pharmacology study of a novel protein-based cancer vaccine CHP-NY-ESO-1. Kobe J Med Sci. 2008 May 23;54(1):E23-34.
・ Uenaka, A., Wada, H., Isobe, M., Saika, T., Tsuji, K., Sato, E., Sato, S., Noguchi, Y., Kawabata, R., Yasuda, T., Doki, Y., Kumon, H,. Iwatsuki, K., Shiku, H., Monden, M., Jungbluth, A., Ritter, G., Murphy, R., Hoffman, E., Old, LJ. and Nakayama, E. : T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein. Cancer Immunity Vol. 7, p9, April 19, 2007
・ Kitano, S., Kageyama, S., Nagata, Y., Miyahara, Y., Hiasa, A., Naota, H., Okumura, S., Imai, H., Shiraishi, T., Masuya, M., Nishikawa, M., Sunamoto, J., Akiyoshi, K., Kanematsu, T., Scott, AM., Murphy, R., Hoffman, EW., Old, LJ.,and Shiku, H. : HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan. Clin. Cancer Res. 2006; 12(24), 7397-7405, December 15, 2006
・ Nishikawa, H., Kato, T., Takawa, I., Saito, K., Ikeda, H., Kuribayashi, K., Allen, P.M., Schreiber, R.D., Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells. J.Exp.Med. 201(5)681-686, 2005.
・ Nishikawa, H., Kato, T., Tawara, I., Ikeda, H., Kuribayashi, K., Allen, P.M., Schreiber, R.D., Old, L.J., and Shiku, H. : IFN-γcontrols the generation/activation of CD4+ CD25+ regulatory T cells in antitumor Immune response. J. Immunology 175, 4433-4440, 2005.
・ Miyahara, Y., Naota, H., Wang, L., Hiasa, A., Goto, M., Watanabe, M., Kitano, S., Okumura, S., Takemitsu, T., Yuta, A., Majima, Y., Lemonnier, F. A., Boon and Shiku, H. : Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ lines, MAGE-A4 and SAGE. Clin. Cancer Res. 2005;11(15), 5581-5589, 2005.
・ Nishikawa, H., Kato, T., Tawara, I., Takemitsu, T., Saito, K., Wang, L., Ikarashi, Y., Wakasugi, H., Nakayama, T., Taniguchi, M., Kuribayashi, K., Old, L.J., and Shiku, H. : Accelerated chemically induced tumor development mediated by CD4+ CD25+ regulatory T cells in wild-type hosts. Proc. Natl. Acad. Sci. USA. 102:9253-9257, 2005.
・ Nishikawa, H., Kato, T., Tanida, K., Hiasa, A., Tawara, I., Ikeda, H., Ikarashi, Y., Wakasugi, H., Kronenberg, M., Nakayama, T., Taniguchi, M., Kuribayashi, K., Old, L.J., and Shiku, H. : CD4 +CD25 +T cells responding to serologically defined autoantigens suppress antitumor immune response. Proc. Natl. Acad. Sci. USA. 100:10902-10906, 2003.
・ Wang L, Miyahara Y, Kato T, Wang L, Aota T, Kuribayashi K, Shiku H., Essential roles of tumor-derived helper T cell epitopes for an effective peptide-based tumor vaccine. Cancer Immun. Nov 21;3:16,2003
・ Shiku, H., Importance of CD4+ helper T-cells in antitumor immunity. Int J Hematol. 77:435-8, 2003.
・ Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., and Shiku, H. : Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. International J. Oncology 22:1135-1139, 2003.
・ Ikuta,Y., Katayama, N.,Wang,L., Okugawa,T., Takahashi,Y., Schmitt,M., Gu,X., Watanabe,M., Akiyoshi,K., Nakamura,H., Kuribayashi,K., Sunamoto,J. and Shiku,H. :Presentation of a major histocompatibility complex class 1-binding peptide by monocyte-derived dendritic cells incorporating hydrophobized polysaccharide-truncated HER2 protein complex: implications for a polyvalent immuno-cell therapy. Blood 99:3717-3724, 2002.
・ Mukai, K., Yasutomi, Y., Watanabe, M., Kenjo, A., Aota, T., Wang, L., Nishikawa, H., Ishihara, M., Fujita, T., Kuribayashi, K. and Shiku, H .: HER2 peptide-specific CD8(+) T cells are proportionally detectable long after multiple DNA vaccinations. Gene Ther. 9:879-888, 2002.
・ Nishikawa, H., Tanida, K., Ikeda, H., Sakakura, M., Miyahara, Y., Aota, T., Mukai, K., Watanabe, M., Kuribayashi, K., Old, LJ. and Shiku, H. : Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor specific immunity. Proc. Natl. Acad. Sci. USA. 98:14571-14576, 2001.
・ Shiku, H., Wang, L., Ikuta, Y., Okuguwa, T., Schmidt, M., Gu, X., Akiyoshi, K., Sunamoto, J., Nakamura, H. :Development of a cancer vaccine: peptides, proteins, and DNA. Cancer Chemother. Pharmacol. 46(Suppl) S77-S82, 2000.
・ Ikuta Y, Okugawa T, Furugen R, Nagata Y, Takahashi Y, Wang L, Ikeda H, Watanabe M, Imai S, Shiku H., A HER2/NEU-derived peptide, a K(d)-restricted murine tumor rejection antigen, induces HER2-specific HLA-A2402-restricted CD8(+) cytotoxic T lymphocytes. Int J Cancer. 15;87(4):553-8,2000
・ Okugawa, T., Ikuta, Y., Takahashi, Y., Obata, H., Tanida, K., Watanabe, M., Imai, S., Furugen, R., Nagata, Y., Toyoda, N. and Shiku, H. : A novel human HER2-derived peptide homologous to the mouse K(d) -restricted tumor rejection antigen can induce HLA-A24 restricted cytotoxic T lymphocytes in ovarian cancer patients and healthy individuals. Eur. J. Immunol. 30 : 3338-3346, 2000.
・ Gu, X., Schmidt, M., Hiasa, A., Nagata, Y., Ikeda, H., Sasaki, Y., Akiyoshi, K., Sunamoto, J., Nakamura, H., Kuribayashi, K. and Shiku, H. : A novel hydrophobized polysaccharide/oncoprotein complex vaccine Induces in vitro and in vivo cellular and humoral Immune responses against HER2-expressing murine sarcomas. Cancer Res. 58: 3385-3390, 1998.
・ Nagata, Y., Furugen, R., Hiasa , A., Ikeda, H., Ohta , N., Furukawa, K., Nakamura, H., Furukawa, K., Kanematsu, T. and Shiku, H. : Peptides derived from a wild type murine proto- oncogene c-erB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts. J. Immunol . 159: 1336-1343, 1997.
・ Ikeda, H., Ohta, N., Furukawa, K., Miyazaki, H., Wang, L., Kuribayashi, K., Old, L.J. and Shiku, H. : Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma. Proc. Natl. Acad. Sci. USA 94: 6375-6379, 1997.

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