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Cancer DNA Vaccines

@Technology of DNA vaccines is the most advanced immunization method which utilizes molecular biology techniques that inoculates antigens into the body in the form of ggenesh encoding antigen proteins. DNA vaccines can be administered in a form of plasmid DNA or viral vectors, etc. For example, when DNA vaccines are subcutaneously administered as plasmid DNA, the plasmid DNA is incorporated into antigen presenting cells and produces the intended antigen protein (see the following Figure). Thereafter, like protein vaccines, antigen protein is presented to and activate antigen-specific T cells.
@Compared with protein vaccines, DNA vaccines have some advantages. For example, the manufacturing process is relatively easier. In addition, it is one of the features of DNA vaccines that there is large room for further improvement of making it more efficient. Paying attention especially to this point, we are developing gmultifunctional and highly efficient cancer DNA vaccinesh carrying genes of various immunostimulating molecules, in addition to genes encoding antigen protein, in order to totally activate the immune system. Some prototypes of our DNA vaccines are now under evaluation. For example, we are conducting the preclinical efficacy testings of prototype DNA vaccines carrying multiple components of antigen proteins for killer and helper T cells and immunostimulating molecules that activate antigen presenting cells and T cells and signaling molecules that suppress regulatory T cells. We will lead these DNA vaccines to the clinical studies through the process of safety confirmation in non-clinical studies.

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